Twenty to thirty percent of chronic stage cases present severe cardiac symptoms such as heart failure, localized aneurysms and cardiomyopathy. It occurs in two stages, an acute stage (usually asymptomatic) and a chronic stage.

cruzi-contaminated food and drinks, and congenitally. CD is transmitted through a triatomine vector, organ transplants, blood transfusions, T. CD originated in the Americas but is now found globally due to population movements. These results provide further insight into CD pathogenesis and demonstrate the advantage of a systematic spatial perspective to understand infectious disease tropism.Ĭhagas disease (CD) is a tropical disease caused by the parasite Trypanosoma cruzi. cruzi strains and identified select infection-modulated pathways. Overall, our study indicated global and positional metabolic differences common to infection with different T. In addition, we identified acylcarnitines and glycerophosphocholines as discriminatory chemical families within each heart region, comparing infected and uninfected samples. These sites were distinct from the sites of highest parasite burden.

cruzi infection, indicating that parasite infection changes the host metabolome at specific sites in chronic CD. Our data showed chemical differences in localized cardiac regions upon chronic T. Using spatial metabolomics (chemical cartography), we sought to understand the localized impact of chronic CD on the cardiac metabolome of mice infected with two divergent T. However, these cardiac clinical manifestations and CD pathogenesis are not fully understood. cruzi infects 7–8 million people worldwide and can induce severe cardiac symptoms including apical aneurysms, thromboembolisms and arrhythmias during the chronic stage of CD. cruzi-contaminated food and drinks, and congenital transmission.

CD is a vector-borne disease transmitted by triatomines, but CD can also be transmitted through blood transfusions, organ transplants, T. Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is one of nineteen neglected tropical diseases.

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